An artificial CO-releasing metalloprotein built by histidine-selective metallation

作者：Albuquerque Ines S; Jeremias Helia F; Chaves Ferreira Miguel; Matak Vinkovic Dijana; Boutureira Omar; Romao Carlos C; Bernardes Gonalo J L^*

来源：Chemical Communications, 2015, 51(19): 3993-3996.

DOI：10.1039/c4cc10204e

We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)(2)(H2O)(4)](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-Ru-II(CO)(2) metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.

• 出版日期2015