Design, synthesis, in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial, antifungal and anti-tubercular agents

作者：Akhaja Tarunkumar Nanjibhai; Raval Jignesh Priyakant^*

来源：Chinese Chemical Letters, 2012, 23(4): 446-449.

DOI：10.1016/j.cclet.2012.01.040

• Tetrahydropyrimidines
• Isatin
• 1,3-Dihydro-2H-indol-2-ones
• Biginelli reaction
• CaCl2 catalyst
• In vitro antituberculer activity
• Antibacterial and antifungal activity

A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2-ylimino)indolin-2-one derivatives were synthesized, characterized and were screened for anti-bacterial, anti-fungal and antitubercular activity.

• 出版日期2012-4