Size-Based Distributions of Postprandial Lipoproteins in Lymph and Serum ester Oral Administration of Triacylglycerol and Diacylglycerol Oils in Rafts

作者：Saito Shinichiro^*; Nakagiri Hideaki; Watanabe Hiroyuki; Matsuo Noboru; Tokimitsu Ichiro; Okazaki Mitsuyo

来源：Journal of Nutritional Science and Vitaminology, 2008, 54(6): 491-496.

• diacylglycerol
• triacylglycerol
• lipoprotein
• HPLC
• rat

Several studies in humans and rodents suggest: that postprandial serum triglyceride (TG) levels are decreased by a single oral administration of diacylglycerol (DAG) oil compared with administration of control triacylglycerol (TAG) oil, To gain further insight into the mechanisms underlying the metabolic properties of DAG in a postprandial state, we analyzed the size-based distributions of postprandial lipoproteins in the lymph and serum using gel filtration-based high-performance liquid chromatography. In thoracic duct lymph pooled for 3 h after oral administration of TAG or DAG, the size-based distributions of postprandial lymphatic lipoprotein-TG and -cholesterol levels did not differ significantly, suggesting that DAG did not: affect the size of lipoprotein particles secreted from the small intestine. Serum lipoprotein-TG (60%) and -cholesterol levels (90%), however, were significantly different among fractions with a diameter of greater than 80 urn 1. to 2 h after the administration of DAG compared to TAG. In addition, there was a considerable, but nonsignificant, reduction in lipoprotein-TG levels (similar to 40%) in fractions with a diameter of 80 to 30 nm, suggesting that DAG-derived chylomicrons as well as DAG-derived chylomicron remnants were catabolized rapidly. In conclusion, dietary DAG reduced the amount: of large-size lipoproteins in the serum, but, did not: affect: the size distribution of lipoproteins produced in the small intestine. Thus, compared with TAG, dietary DAG may reduce the postprandial serum total TG levels.

• 出版日期2008-12