Double Allogenic Mesenchymal Stem Cells Transplantations Could Not Enhance Therapeutic Effect Compared with Single Transplantation in Systemic Lupus Erythematosus

作者：Wang, Dandan; Akiyama, Kentaro; Zhang, Huayong; Yamaza, Takayoshi; Li, Xia; Feng, Xuebing; Wang, Hong; Hua, Bingzhu; Liu, Bujun; Xu, Huji; Chen, Wanjun; Shi, Songtao^*; Sun, Lingyun

来源：Clinical and Developmental Immunology, 2012, 273291.

DOI：10.1155/2012/273291

• VERSUS-HOST-DISEASE
• STROMAL CELLS
• LIVER-CIRRHOSIS
• MRL/LPR MICE
• SCLEROSIS
• TRIAL
• IMMUNOTHERAPY
• IMPROVEMENT
• NEPHRITIS
• EFFICACY

The clinical trial of allogenic mesenchymal stem cells (MSCs) transplantation for refractory SLE patients has shown significant safety and efficacy profiles. However, the optimum frequency of the MSCs transplantation (MSCT) is unknown. This study was undertaken to observe whether double transplantations of MSCs is superior to single transplantation. Fifty-eight refractory SLE patients were enrolled in this study, in which 30 were randomly given single MSCT, and the other 28 were given double MSCT. Patients were followed up for rates of survival, disease remission, and relapse, as well as transplantation-related adverse events. SLE disease activity index (SLEDAI) and serologic features were evaluated. Our results showed that no remarkable differences between single and double allogenic MSCT were found in terms of disease remission and relapse, amelioration of disease activity, and serum indexes in an SLE clinical trial with more than one year followup. This study demonstrated that single MSCs transplantation at the dose of one million MSCs per kilogram of body weight was sufficient to induce disease remission for refractory SLE patients.

• 出版日期2012
• 单位天津市中医药研究院附属医院; 南京大学; NIH; 中国人民解放军第二军医大学