Phytoconstituents from Sidastrum micranthum (A. St.-Hil.) Fryxell (Malvaceae) and antimicrobial activity of pheophytin a

作者：Gomes Roosevelt Albuquerque; Ferreira Teles Yanna Carolina; Pereira Fillipe de Oliveira; de Sousa Rodrigues Luis Alberto; Lima Edeltrudes de Oliveira; Agra Maria de Fatima; Vanderlei de Souza Maria de Fatima

来源：Brazilian Journal of Pharmaceutical Sciences, 2015, 51(4): 861-867.

DOI：10.1590/S1984-82502015000400012

• Malvaceae/phytochemistry
• Sidastrum micranthum/phytochemistry
• Sidastrum micranthum/antimicrobial activity/in vitro study
• Pheophytins
• Medicinal plants

Sidastrum micranthum (A. St.-Hil.) Fryxell, a member of the Malvaceae family, is called malva preta in Brazil. As this species is commonly used to treat bronchitis, cough, and asthma, better knowledge of its chemical compounds is important. The phytochemical study of its hexane extract, using chromatographic techniques, led to isolation of six compounds: the triterpene isoarborinol, a mixture of sitosterol and stigmasterol, sitosterol-3-O-beta-D-glucopyranoside, pheophytin a, and 13(2)-hydroxy-(13(2)-S)-pheophytin a. Structural identification of these compounds was carried out using spectroscopic methods such as IR and 1D and 2D NMR (HOMOCOSY, HMQC, HMBC, and NOESY). Compounds isolated from S. micranthum were screened for their in vitro antifungal and antibacterial activity against twenty fungal and bacterial standard strains. Pheophytin a exhibited antimicrobial action against all microorganisms tested.

• 出版日期2015-12