A GREEN AND EFFICIENT APPROACH FOR THE SYNTHESIS OF 3-CHALCOGEN BENZO[B]FURANS VIA I-2-MEDIATED CASCADE ANNULATION REACTION OF 2-ALKYNYLANISOLES AT ROOM TEMPERATURE IN WATER

作者：Han Jiang Sheng; Shao Yin Lin; Zhang Xiao Hong^*; Zhong Ping

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2013, 188(11): 1599-1610.

DOI：10.1080/10426507.2013.770738

• 3-chalcogen benzo[b]furans
• I-2-mediated intramolecular annulation

An efficient and green aqueous protocol to access 3-chalcogen benzo[b]furan derivatives has been developed. The reaction can proceed via I-2-mediated intramolecular annulation reaction of 2-alkynylanisoles with diaryl disulfides (diselenides) in water or under solvent-free conditions at room temperature. With the participation of I-2, a variety of 3-chalcogen benzo[b]furan derivatives were obtained in good to excellent yields. This reaction was considered to work via an iodocyclization cascade mechanism and the intermediate 3-iodo-2-phenylbenzofuran was detected by GC-MS.

• 出版日期2013-11-1
• 单位温州大学