DETERMINATION OF DIMETHYLFUMARATE IN LEATHER AND FOOTWEAR BY SOLID-PHASE MICRO EXTRACTION AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY

作者：Cuadros R M^*; Font J; Reyes M; Olle L L; Marsal A

来源：Journal of the American Leather Chemists Association, 2010, 105(12): 395-400.

In the last two years, Europe has experienced a rise in skin allergy and dermatitis due to goods of an Asian provenance that have been treated with dimethylfumarate (DMFU). Accordingly, laboratories in the leather and footwear sectors have been obliged to develop analytical methods to determine the presence of this substance given the absence of an official method. The ban on DMFU as laid down in Decision 2009/251 of the European Union establishes a maximum concentration of DMFU in products of 0.1 mg/kg. A simple non-destructive rapid method based on manual headspace solid-phase micro extraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) is proposed to detect DMFU in leather and footwear. Thereafter, the samples in which DMFU is detected are analysed by a solid-liquid extraction (SLE) with acetone after which DMFU is quantitatively determined by GC-MS. The quantitative method is validated in terms of linearity, precision, sensitivity and recovery; demonstrating its reliability. Quantification is performed using naphthalene-D8 as internal standard. The detection limits are 0.005 mg/kg and 0.03 mg/kg for the HS-SPME-GC-MS and SLE-GC-MS methods, respectively. Given that these limits are below the maximum limit of 0.1 mg/kg imposed by the European Union, the proposed methods are suitable for determining DMFU content in real samples.

• 出版日期2010-12