No single irreplaceable acidic residues in the Escherichia coli secondary multidrug transporter MdfA

作者:Sigal Nadejda; Molshanski Mor Shahar; Bibi Eitan*
来源:Journal of Bacteriology, 2006, 188(15): 5635-5639.
DOI:10.1128/JB.00422-06

摘要

The largest family of solute transporters (major facilitator superfamily [MFS]) includes proton-motive-force-driven secondary transporters. Several characterized MFS transporters utilize essential acidic residues that play a critical role in the energy-coupling mechanism during transport. Surprisingly, we show here that no single acidic residue plays an irreplaceable role in the Escherichia coli secondary multidrug transporter MdfA.

  • 出版日期2006-8