The relation between blood pressure changes induced by passive leg raising and arterial stiffness

作者：Kamran Haroon; Salciccioli Louis; Kumar Paraag; Pushilin Sergei; Namana Vinod; Trotman Sherlene; Lazar Jason^*

来源：Journal of the American Society of Hypertension, 2010, 4(6): 284-289.

DOI：10.1016/j.jash.2010.09.002

• Passive leg raising
• blood pressure
• pulse wave velocity

Passive leg raising (PLR) elicits cardiorespiratory changes because of intra-thoracic blood pooling. We previously found PLR to lower blood pressure (BP) in healthy subjects. To determine the effects of cardiovascular (CV) risk factors on the PLR BP lowering response, we measured brachial artery, systolic (SBP), diastolic (DBP), and pulse pressure (PP) before and 1 minute after 60 PLR, in 125 subjects (58% males, age 48 +/- 18 years) with/without CV risk factors/disease. Baseline carotid-radial pulse wave velocity (PWV) and augmentation index (AI) were measured by applanation tonometry. Changes (A) in SBP and BA PP ranged from +31 to -27 and +35 to -20 mm Hg and were normally distributed. Mean BP decreases upon PLR were Delta SBP -3 +/- 9 (P < .001), and APP -2 +/- 8 mm Hg (P = .04). On univariate analyses, ASBP was correlated with age (r = 0.31, P < .001), PWV (r = 0.53, P < .001), AI (r = 0.25, P < .01), hypertension (r = 0.37, P < .001), hypercholesterolemia (r = 0.25, P < .01) and renal insufficiency (r = 0.19, P = .038). APP was correlated with age (r = 0.31, P < .001), PWV (r = 0.45, P < .001), AI (r = 0.23, P = .01), hypertension (r = 0.22, P = .01), hypercholesterolemia (r = 0.27, P < .001). Multivariate analysis showed PWV the only independent predictor of ASBP (B = 3.2, r(2) = 0.40, P < .001) and of APP (B = 2.6, r(2) = 0.36, P < .001). Therefore, changes in SBP and PP induced by PLR are independently and inversely related to carotid-radial PWV. J Am Soc Hypertens 2010;4(6):284-289. Published by Elsevier Inc on behalf of American Society of Hypertension.

• 出版日期2010-12