A successful case of pain management using metformin in a patient with adiposis dolorosa

作者：Labuzek Krzysztof^*; Liber Sebastian; Suchy Dariusz; Okopien Boguslaw

来源：International Journal of Clinical Pharmacology and Therapeutics, 2013, 51(6): 517-524.

DOI：10.5414/CP201878

• adiponectin
• leptin
• resistin
• mu-receptors
• adiposis dolorosa
• Dercum's disease

In this case report, we describe a patient with Dercum's disease who was successfully managed with metformin. The administration of metformin reduced pain intensity from 9/10 to 3/10 and favorably affected the profile of inflammatory cytokines (i.e., TNF a, IL-1 beta, IL-6, and IL-10), adipoIdnes (i.e., adiponectin, leptin, and resistin), and beta-endorphin. Because each variable was affected moderately by the drug, in the range of 20 30%, it follows that these effects are additive, i.e., they act independently of each other. However, taking into account advances in the pharmacology of metformin, it seems that other phenomena, such as modulation of synaptic plasticity, activation of microglia, and autophagy of the afferents supplying painful lipomas should be taken into consideration. Nonetheless, metformin deserves further exploration in the biology of pain.

• 出版日期2013-6