A new magnetic resonance imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for long-term detection of tumors

作者：Rigaux G^*; Roullin V G; Cadiou C; Portefaix C; Van Gulick L; Baeuf G; Andry M C; Hoeffel C; Elst L Vander; Laurent S; Muller R; Molinari M; Chuburu F

来源：Nanotechnology, 2014, 25(44): 445103.

DOI：10.1088/0957-4484/25/44/445103

• MRI contrast agents
• gadolinium complex
• PLGA nanoparticles
• biocompatible materials

The incorporation of a lipophilic Gd chelate (GdDO3A-C-12) in biocompatible PLGA poly(D, L-lactide- co-glycolide) nanoparticles was explored as an approach to increase the relaxivity of contrast agents for magnetic resonance imaging. By nanoprecipitation, it was possible to obtain PEGylated gadolinium nanoparticles (mean diameter of 155 nm) with high Gd loading (1.1 x 10(4) Gd centers per nanoparticle). The corresponding GdDO3AC(12) subset of NPs nanoparticles exhibited an enhanced relaxivity (up to sixfold greater than DOTAREM (R) at 40 MHz) because the nanoparticle framework constrained the lipophilic Gd chelate motion and favorably impacted the Gd chelate rotational correlation time. T-1-weighted imaging at 3 T on phantoms showed enhanced contrast for the GdDO3AC12. NPs. Importantly, Gd chelate leakage was almost nonexistent, which suggested that these GdDO3AC12. NPs could be useful for long-term MRI detection.

• 出版日期2014-11-7