Asymmetric Intermolecular Conjugate Addition of Amino Acid Derivatives via Memory of Chirality: Total Synthesis of Manzacidin A

作者：Yoshimura Tomoyuki; Kinoshita Tomohiko; Yoshioka Hiroyasu; Kawabata Takeo^*

来源：Organic Letters, 2013, 15(4): 864-867.

DOI：10.1021/ol303568f

Asymmetric intermolecular conjugate addition of a-amino acid derivatives with 4 via memory of chirality has been developed. The reactions proceeded in up to 98% ee with retention of configuration at the newly formed tetrasubstituted carbon center when R = Me. The product (R = Me) was transformed into manzacidin A.

• 出版日期2013-2-15