Membrane type 1 matrix metalloproteinase expression correlated with the clinicopathological feature and invasion and metastasis in oral squamous cell carcinoma

作者：Zhou, Mei-Ling; Wang, Qiong; Xu, Xiao-Hui; Zhang, Wei; Yang, Cong-Chong^*; Liu, Lai-Kui^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(2): 1186-1198.

• Membrane type 1 matrix metalloproteinase
• oral squamous cell carcinoma
• prognosis

In the current study, we intended to analyze the expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in oral squamous cell carcinoma (OSCC) and its correlations with clinicopathologic characteristic, and to further identify the function of MT1-MMP in promoting cancer invasion from the point of view of the extracellular matrix degradation. We collected 122 cases of OSCC tissue specimens from patients. Test results were correlated with clinical and pathological parameters. The effects of MT1-MMP in oral cancer cells on the regulation of associated MMPs expression and the invasive and migratory abilities were analyzed. Our results demonstrated that the high expression of MT1-MMP in tumors significantly correlated with the lymph node metastasis, pathological grade, recurrence and follow-up, and high expression of MT1-MMP at the invasive front of tumor significantly correlated with the lymph node metastasis. Furthermore, the patients with higher expression of MT1-MMP had shorter survival time in OSCC. Multivariate analysis indicated that MT1-MMP expression could serve as an independent prognostic indicator for the survival of patients with OSCC. In addition, MT1-MMP, through regulating associated MMPs expression, contributes to promoting the invasion and metastasis in oral cancer cells. In conclusion, MT1-MMP may play an important role in OSCC invasion and metastasis and could act as a promising target for prognostic prediction.

• 出版日期2017
• 单位南京医科大学