Abnormal thyroid function tests in children on ethionamide treatment

作者：Thee S^*; Zoellner E W; Willemse M; Hesseling A C; Magdorf K; Schaaf H S

来源：International Journal of Tuberculosis and Lung Disease, 2011, 15(9): 1191-1193.

DOI：10.5588/ijtld.10.0707

• ethionamide
• children
• tuberculosis
• thyroid function

Ethionamide (ETH) treatment may cause hypothyroidism. Clinical data, scrum thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels were retrospectively assessed in 137 children receiving anti-tuberculosis treatment including ETH. Abnormal thyroid function tests (TFTs) were recorded in 79 (58%) children: elevated serum TSH and suppressed fT4 (n = 30), isolated elevated serum TSH (n = 20), isolated low serum fT4 (n = 28) and isolated low TSH (n = 1). The risk for biochemical hypothyroidism was higher for children on regimens including para-aminosalicylic acid and in human immunodeficiency virus infected children. TFT abnormalities are frequent in children on ETH and are mainly due to primary hypothyroidism or euthyroid sick syndrome.

• 出版日期2011-9