Macular Retinal Ganglion Cell Layer Thickness Is Not Reduced in Patients with Obstructive Sleep Apnea

作者：Ferrandez Blanca; Ferreras Antonio^*; Calvo Pilar; Abadia Beatriz; Pajarin Ana B; Marin Jose M; Iester Michele

来源：Ophthalmic Research, 2016, 56(2): 85-91.

DOI：10.1159/000445353

• Obstructive sleep apnea
• Visual field
• Optical coherence tomography
• Ganglion cell layer

Purpose: To evaluate macular ganglion cell layer (GCL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses in patients with obstructive sleep apnea (OSA) syndrome. Methods: 73 OSA patients and 67 age-matched controls were consecutively and prospectively enrolled. All participants underwent at least one reliable standard automated perimetry (SAP) and were imaged with spectral-domain optical coherence tomography (OCT) using two different devices. The OCT parameters were compared between groups, and Pearson correlations between main indices of SAP and OCT parameters were calculated. Results: The pattern standard deviation of SAP was higher in the OSA group (p = 0.001). Mean GCIPL thickness was 82.99 +/- 10.30 and 80.78 +/- 12.15 mu m in the control and OSA groups, respectively (p = 0.25), and GCL thickness was 44.93 +/- 11.42 mu m in the control group and 48.81 +/- 10.85 mu m in OSA individuals (p = 0.47). Pearson correlations between the GCIPL-GCL measurements and the main indices of SAP were not significant. Conclusions: Neither GCIPL nor GCL thickness were reduced in OSA subjects compared with healthy individuals. Retinal sensitivity evaluated with SAP was however decreased in OSA patients.

• 出版日期2016