Anticoagulation therapy for a LVAD patient with acquired warfarin resistance

作者：Yoshioka Daisuke; Toda Koichi; Hidaka Takayuki; Yasuda Soichiro; Saito Shunsuke; Domae Keitaro; Sawa Yoshiki^*

来源：Journal of Artificial Organs, 2017, 20(3): 260-262.

DOI：10.1007/s10047-017-0947-8

• Left ventricular assist device
• Warfarin
• Anticoagulation therapy

Anticoagulation therapy with warfarin is essential for postoperative management in patients with left ventricular assist device (LVAD). In this manuscript, we report the case of a patient who developed warfarin resistance after LVAD implantation. Although we administered a novel anticoagulant drug in addition to warfarin and aspirin therapy, the patient developed a major stroke. The patient needed continuous intravenous heparinization until heart transplantation for approximately 2 years. Meticulous management of anticoagulation therapy is essential for a LVAD with warfarin resistance. To our best knowledge, our case is the first case of warfarin resistance in a patient with LVAD.

• 出版日期2017-9