A photochemical flow reactor for large scale syntheses of aglain and rocaglate natural product analogues

作者：Yueh Han; Gao Qiwen; Porco John A Jr; Beeler Aaron B^*

来源：Bioorganic & Medicinal Chemistry, 2017, 25(23): 6197-6202.

DOI：10.1016/j.bmc.2017.06.010

• Photochemistry
• Flow chemistry
• ESIPT
• Photocycloaddition
• Rocaglate
• Natural product
• Aglain

Herein, we report the development of continuous flow photoreactors for large scale ESIPT-mediated [3+2]-photocycloaddition of 2-(p-methoxyphenyl)-3-hydroxyflavone and cinnamate-derived dipolarophiles. These reactors can be efficiently numbered up to increase throughput two orders of magnitude greater than the corresponding batch reactions.

• 出版日期2017-12-1