Neutrophil activation via beta(2) integrins (CD11/CD18): Molecular mechanisms and clinical implications

作者：Schymeinsky Jorgen; Mocsai Attila; Walzog Barbara^*

来源：Thrombosis and Haemostasis, 2007, 98(2): 262-273.

DOI：10.1160/TH07-02-0156

• integrins
• inflammation
• leukocyte trafficking/recruitment
• signal transcluction

Polymorphonuclear neutrophils (PMN) are key components of the innate immunity and their efficient recruitment to the sites of lesion is a prerequisite for acute inflammation. Signaling via adhesion molecules of the beta(2) integrin family (CDII/CD18) plays an essential role for PMN recruitment and activation during inflammation. In this review, we will focus on the non-receptor tyrosine kinase Syk, an important downstream signaling component Of beta(2) integrins that is required for the control of different PMN functions including adhesion, migration and phagocytosis. The exploration of beta(2) integrin-mediated Syk activation provided not only novel insights into the control of PMN functions but also led to the identification of Syk as a new molecular target for therapeutic intervention during inflammatory diseases.

• 出版日期2007-8