Asymmetric cross-coupling of potassium 2-butenyltrifluoroborates with aryl and 1-alkenyl bromides catalyzed by a Pd(OAc)(2)/Josiphos complex

作者：Yamamoto Yasunori^*; Takada Shingo; Miyaura Norio

来源：Chemistry Letters, 2006, 35(12): 1368-1369.

DOI：10.1246/cl.2006.1368

The asymmetric cross-coupling reaction of [CH3CH=CHCH2BF3]K with aryl or 1-alkenyl bromides selectively occurred at the gamma-carbon of 2-butenylborane moiety with regioselectivities in a range of 84-99%. The enantioselectivities were in a range of 77-90%ee when a palladium/CyPF-t-Bu complex was used at 80 degrees C in the presence of K2CO3 (3 equiv.) in H2O-MeOH (9/1).

• 出版日期2006-12-5