Mitochondria in relation to cancer metastasis

作者：Bhandary Bidur; Marahatta Anu; Kim Hyung Ryong; Chae Han Jung^*

来源：Journal of Bioenergetics and Biomembranes, 2012, 44(6): 623-627.

DOI：10.1007/s10863-012-9464-x

• Cancer metastasis
• Mitochondria
• Glycolysis
• ROS
• Apoptosis

Mitochondria, also known as %26quot;Power House of cell,%26quot; are crucial organelles, regulating energy metabolism. Recently, an involvement of mitochondria in cancer occurrence and metastasis has been proposed. The roles of mitochondria in cancer progression/metastasis include alteration of glycolysis, regulation of ROS and suppression of intrinsic apoptosis. This mini-review explains the specific mitochondrial characteristics during cancer metastasis with past and recent findings. It may contribute to understanding mitochondria-related mechanisms of cancer metastasis.

• 出版日期2012-12