Generation of Diverse 2H-Isoindol-1-ylphosphonates via Three-Component Reaction of 2-Alkynylbenzaldehyde, Aniline, and Phosphite

作者：Yu, Xingxin; Ding, Qiuping; Wu, Jie^*

来源：Journal of Combinatorial Chemistry, 2010, 12(5): 743-746.

DOI：10.1021/cc100101a

• ALPHA-AMINO PHOSPHONATES
• ONE-POT SYNTHESIS
• ORGANIC-SYNTHESIS
• TRANSITION-METAL
• EFFICIENT ROUTE
• MULTICATALYTIC SYNTHESIS
• LANTHANIDE TRIFLATE
• CASCADE CATALYSIS
• DOMINO REACTIONS
• TANDEM REACTIONS

Diverse 2H-isoindol-1-ylphosphonates as potential HCT-116 inhibitors are easily generated via a FeCl(3) and PdCl(2) cocatalyzed three-component reaction of 2-alkynylbenzaldehyde, aniline, and phosphite. The focused small library is constructed based on parallel diversity-oriented synthesis.

• 出版日期2010-10
• 单位江西师范大学; 复旦大学