Antiganglion neuron antibodies correlate with neuropathy in Sjogren's syndrome

作者：Murata Y; Maeda K^*; Kawai H; Terashima T; Okabe H; Kashiwagi A; Yasuda H

来源：NeuroReport, 2005, 16(7): 677-681.

DOI：10.1097/00001756-200505120-00005

To investigate the possible implication of antibodies against dorsal root ganglion neuron in the pathogenesis of sensory neuropathy with Sjogren's syndrome, we examined the pathogenic role of antiganglion neuron antibodies by immunoblotting, immunohistochemistry and immunoreactive assay. Sjogren's syndrome patients without neuropathy, patients with vasculitic neuropathy and normal volunteers were evaluated as controls. Antiganglion neuron antibodies recognizing certain proteins of several different molecular weights were detected only in patients of sensory neuropathy with Sjogren's syndrome. Those antibodies labeled specific-sized neurons in the fixed ganglion and isolated ganglion neurons under the culture condition, each of which corresponded well to clinical manifestations. These results suggest that antiganglion neuron antibodies may contribute to the pathogenesis of sensory neuropathy with Sjogren's syndrome. NeuroReport 16:677-681 © 2005 Lippincott Williams & Wilkins.

• 出版日期2005-5-12