Ammonia-induced deficit in corticostriatal long-term depression and its amelioration by zaprinast

作者：Chepkova Aisa N; Selbach Oliver; Haas Helmut L; Sergeeva Olga A^*

来源：Journal of Neurochemistry, 2012, 122(3): 545-556.

DOI：10.1111/j.1471-4159.2012.07806.x

• ammonia
• DHPG
• green tea polyphenols
• long-term depression
• striatum
• zaprinast

J. Neurochem. (2012) 122, 545556. Abstract Hyperammonemia is a major pathophysiological factor in encephalopathies associated with acute and chronic liver failure. On mouse brain slice preparations, we analyzed the effects of ammonia on the characteristics of corticostriatal long-term depression (LTD) induced by electrical stimulation of cortical input or pharmacological activation of metabotropic glutamate receptors. Long exposure of neostriatal slices to ammonium chloride impaired the induction and/or expression of all studied forms of LTD. This impairment was reversed by the phosphodiesterase inhibitor zaprinast implying lowered cGMP signaling in LTD suppression. Polyphenols from green tea rescued short-term corticostriatal plasticity, but failed to prevent the ammonia-induced deficit of LTD. Zaprinast counteracts the ammonia-induced impairment of long-term corticostriatal plasticity and may thus improve fine motor skills and procedural learning in hepatic encephalopathy.

• 出版日期2012-8