Adiponectin is Not Associated With Blood Pressure in Normotensives and Untreated Hypertensives With Normal Kidney Function

作者：Ivkovic Vanja^*; Jelakovic Mislav; Laganovic Mario; Pecin Ivan; Vrdoljak Ana; Karanovic Sandra; Fucek Mirjana; Bozina Tamara; Kos Jelena; Vrkic Tajana Z Eljkovic; Premuzic Vedran; Zivko Marijana; Jelakovic Bojan

来源：Medicine, 2014, 93(28): e250.

DOI：10.1097/MD.0000000000000250

The role of adiponectin in hypertension is still a matter of debate. Obtained conflicting results could be mostly explained with diversity of subjects included in different studies. Our aim was to analyze association of adiponectin with blood pressure (BP) in a group of normotensive and untreated hypertensive subjects. %26lt;br%26gt;Participants (N = 257) were selected from a random sample of 2487 subjects enrolled in an observational cross-sectional study. Subjects with diabetes and chronic kidney diseases were excluded. BP was measured using Omron M6 device following ESH/ESC guidelines. Adiponectin concentration was determined by ELISA. %26lt;br%26gt;There were no differences in adiponectin values (mg/L) between hypertensives and normotensives (median 9.75; iqr: 7.44-17.88 vs 11.35; iqr: 7.43-12.63; P = 0.17). On univariate linear regression adiponectin was not associated with systolic or diastolic BP (P %26gt; 0.05). Furthermore, multivariate analysis did not show significant contribution of log-transformed adiponectin either to systolic (beta = -0.040; P = 0.43) or diastolic BP (beta = 0.066; P = 0.33). %26lt;br%26gt;In our group of normotensives and untreated hypertensives with normal kidney function adiponectin was not associated with BP even after adjustment for other risk factors. Our results and conclusions should not be extrapolated to subjects with other characteristics.

• 出版日期2014-12