A fast ruthenium polypyridine cage complex photoreleases glutamate with visible or IR light in one and two photon regimes

作者：Salierno Marcelo; Marceca Ernesto; Peterka Darcy S; Yuste Rafael; Etchenique Roberto^*

来源：Journal of Inorganic Biochemistry, 2010, 104(4): 418-422.

DOI：10.1016/j.jinorgbio.2009.12.004

• Caged compounds
• Phototriggers
• Two photon
• Glutamate
• Neuron
• Ruthenium

We introduce a new caged glutamate, based in a ruthenium bipyridyl core, that undergoes heterolytic cleavage after irradiation with visible light with wavelengths up to 532 rim, yielding free glutamate in less than 50 ns. Glutamate photorelease occurs also efficiently following two-photon (2P) excitation at 800 nm, and has a functional cross section of 0.14 GM.

• 出版日期2010-4