Aurora B kinases restrict chromosome decondensation to telophase of mitosis

作者：Vas Amit C J; Clarke Duncan J^*

来源：Cell Cycle, 2008, 7(3): 293-296.

• chromosome condensation
• aurora B
• Ipl1
• condensin
• topoisomerase II

The Aurora kinases comprise a family of evolutionary conserved serine/ threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome segregation. Vertebrates have three Aurora kinases, Aurora-A, -B and -C, while invertebrates have only Aurora-A and -B and yeasts have a single Aurora kinase, Ipl1 in S. cerevisiae and Ark1 in S. pombe. Recently, the role of Aurora kinases in chromosome condensation has been defined; Aurora B plays a crucial role in the axial shortening of chromosomes during anaphase, presumably in order to prevent chromosome arms from becoming trapped within the cytokinetic plate.

• 出版日期2008-2-1