A core-shell silica nanosphere for the off-on chemosensor of iron(III) ions and the targeted probe for optical imaging on HeLa cells

作者：Tao, Gen-Ping; Chen, Qiu-Yun^*; Yang, Xia; Wang, Kai-Ya

来源：Dyes and Pigments, 2012, 95(2): 338-343.

DOI：10.1016/j.dyepig.2012.04.023

• Core-shell
• Nanoparticies
• Fe(III) ions
• Chemosensor
• Imaging
• Cancer

Rhodamine B isothiocyanate doped silica-coated (RBITC-SiO2) silica nanoparticles were used as three-dimensional scaffolds for fluorophore organization. Di(2-propylcarboxyl)amine (-NH-COOH) groups were conjugated onto the surface of the RBITC@SiO2 forming a stable water soluble nanospheres (RBITC@SiO2-NH-COOH), which could sensitize Fe3+ ions selectively. State fluorescence measurements allowed us to observe the occurrence of an efficient energy transfer process from coordinated Fe3+ ions to the hosted RBITC resulting the turn-off of the emission of RBITC@SiO2-NH-COOH in water solution. Furthermore, the nanosphere (RBITC@SiO2-NH-COOH) displays enhanced HeLa cells fluorescence imaging in vitro suggesting selective cancer cell payload delivery. It represents a class of novel multifunctional nanoparticles that combines the advantages of active cancer-targeting, compatibility with fluorescence imaging and chemosensors of Fe3+ ions.

• 出版日期2012-11
• 单位江苏大学