Acute Cytotoxicity Evoked by Tetrabromobisphenol A in Primary Cultures of Rat Cerebellar Granule Cells Outweighs the Effects of Polychlorinated Biphenyls

作者：Zieminska Elzbieta^*; Stafiej Aleksandra; Toczylowska Beata; Lazarewicz Jerzy W

来源：Polish Journal of Environmental Studies, 2012, 21(4): 1079-1087.

• brominated flame retardants
• calcium
• neurotoxicity
• mitochondrial dysfunction
• oxidative stress
• TBBP-A

The aim of this study was to identify, among selected environmental toxins, the substance with the highest in vitro toxicity to neurons combined with the most marked induction of calcium imbalance, oxidative stress and mitochondrial dysfunction. Exposure of primary cultures of rat cerebellar granule cells for 30 min to polychlorinated biphenyls (PCBs) or brominated flame retardants (BFRs) at concentrations of 10-50 mu M identified tetrabromobisphenol A as the compound with the highest toxicity. At a concentration of 25 mu M, apart from the moderate activation of Ca-45 uptake, this BFR induced the most pronounced increase in intracellular Ca2+ concentration, depolarization of mitochondria, and activation of ROS production.

• 出版日期2012