A Direct, Regioselective Palladium-Catalyzed Synthesis of N-Substituted Benzimidazoles and Imidazopyridines

作者：Alonso Jorge; Halland Nis; Nazare Marc^*; R'kyek Omar; Urmann Matthias; Lindenschmid Andreas

来源：European Journal of Organic Chemistry, 2011, 2011(2): 234-237.

DOI：10.1002/ejoc.201001423

• Benzimidazoles
• Nitrogen heterocycles
• Palladium
• Homogeneous catalysis
• Regioselectivity

Unsymmetric, N-substituted benzimidazoles and imidazopyridines can be prepared directly from 2-halonitroarenes and amides through Pd(TFA)(2)/(R)-BINAP-catalyzed cross-coupling and subsequent reductive aminocyclization. This sequence can be conducted by a one-pot procedure. The method is versatile and allows the straightforward, regioselective preparation of these important nitrogen heterocycles.

• 出版日期2011-1