An efficient synthesis of sterically hindered arylboronic acids

作者：Fang H; Kaur G; Yan J; Wang B^*

来源：Tetrahedron Letters, 2005, 46(10): 1671-1674.

DOI：10.1016/j.tetlet.2005.01.064

• palladium-catalyzed borylation
• bis(neopentyl glycolato)diboron
• ortho-arylboronic acids

Boronic acids are important intermediates and molecular recognition moieties in a wide variety of applications. In our research, we have found that the synthesis of ortho-substituted arylboronic acids is problematic with the commonly used bis(pinacolato)diboron in palladium-mediated borylation reactions. As a substitute, we have found that bis(neopentyl glycolato)diboron is a much more efficient borylation agent for the synthesis of sterically hindered ortho-substituted arylboronic acids.

• 出版日期2005-3-7
• 单位山东大学