Noninvasive Assessment of Jugular Venous Pressure via Force-Coupled Single Crystal Ultrasound

作者：Singh Robin; Jaffe Alex; Frydman Galit H; Najia Mohamad Ali Toufic; Wei Zijun; Yang Jason; Majmudar Maulik D^*

来源：IEEE Transactions on Biomedical Engineering, 2018, 65(8): 1705-1710.

DOI：10.1109/TBME.2017.2767828

• Ultrasound
• jugular venous pressure
• central venous pressure
• heart failure
• noninvasive
• medical device
• diagnostics

Objective: we have developed a handheld device for noninvasive quantitative assessment of jugular venous pressure (JVP). Methods: we used a single crystal ultrasound coupled to a force-sensing load cell to measure JVP based on the force necessary to collapse the internal jugular vein (IJV) walls. We used a gelatin-based model system of the IJV to test the ability of single crystal ultrasound to identify the IJV and verified the cross-sectional position and diameter of the vessels with conventional imaging ultrasound. We also tested our prototype device on healthy human volunteers. Results: experiments on model system demonstrated that vessel diameters determined with single crystal ultrasound were in close agreement with the diameters derived from conventional 2-D ultrasound. Proof-ofconcept human experiments demonstrate that single crystal ultrasound can detect the IJV in basal and collapsed states, as compared to gold-standard sonography (insert stats). Assessment of JVP in human volunteers was physiologically consistent with and sensitive to postural changes (supine JVP 6.6 +/- 2.4 mmHg; standing JVP 4.2 +/- 1.9 mmHg (p < 0.0001). Conclusion: noninvasive assessment of JVP could prove valuable in informing rapid clinical decision-making across various pathologies and conditions leading to derangements in intravascular volume status.

• 出版日期2018-8
• 单位河北医科大学; MIT