Altered local field potential activity and serotonergic neurotransmission are further characteristics of the Flinders sensitive line rat model of depression

作者：Voget Mareike; Rummel Julia; Avchalumov Yosef; Sohr Reinhard; Haumesser Jens K; Rea Ellis; Mathe Aleksander A; Hadar Ravit; van Riesen Christoph; Winter Christine^*

来源：Behavioural Brain Research, 2015, 291: 299-305.

DOI：10.1016/j.bbr.2015.05.027

• Major depression
• Flinders sensitive line rats
• Serotonin
• Local field potentials

A significant portion of patients suffering from major depression remains refractory to available antidepressant treatment strategies. This highlights the need for a better understanding of the underlying neuropathology in order to develop rationale-based treatments. Here we aimed to further characterize neurobiological abnormalities of the Flinders Sensitive Line (FSL) rat model of depression. Biochemically, in FSL rats we mainly found increased levels of serotonin in most cortical and subcortical brain regions when compared to controls. Using electrophysiological measurements, in FSL rats we found decreased alpha, beta and low gamma oscillatory activity in the medial prefrontal cortex and nucleus accumbens and decreased alpha and beta as well as increased low gamma oscillatory activity in the subthalamicus nucleus when compared to controls. In summary, we show distinct neurochemical properties in combination with particular oscillatory activity patterns for brain areas thought to be pathophysiologically relevant for depression. Our data contribute to the further understanding of neurobiological alterations in the FSL rat model of depression that could provide a basis for research into future therapeutic strategies.

• 出版日期2015-9-15