Nucleophilic fluorination facilitated by a CsF-CaF2 packed bed reactor in continuous flow

作者：Johansen M B; Lindhardt A T^*

来源：Chemical Communications, 2018, 54(7): 825-828.

DOI：10.1039/c7cc09035h

A simple to prepare, dry and handle packed bed reactor carrying CsF on CaF2, towards nucleophilic fluorinations in continuous flow, is reported. The reactor also proved adaptable for silyl-ether deprotection and trifluoromethylations with Ruppert's reagent. The study includes reactor stability and scale-up investigations.

• 出版日期2018-1-21