A 2-(2'-hydroxyphenyl)quinazolin-4(3H)-one derived fluorescence 'turn on' probe for recognition of Hg2+ in water solution and its live cell imaging

作者：Tang, Lijun^*; Ding, Shuangli; Zhang, Xingrong^*; Zhong, Keli; Hou, Shuhua; Bian, Yanjiang

来源：Journal of Photochemistry and Photobiology A: Chemistry , 2017, 340: 15-20.

DOI：10.1016/j.jphotochem.2017.03.001

• Hg2+ recognition
• Quinazolin-4(3H)-one
• Dithioacetal
• Fluorescent probe
• Cell imaging

A new fluorescence "turn on" Hg2+ probe 3,3'-(((2-hydroxy-5-methyl-3-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl) methylene)bis(sulfanediyl))dipropionic acid (QBDA) based on Hg2+ -triggered transformation of dithioacetal to aldehyde has been developed. Probe QBDA exhibits high selectivity and sensitivity to Hg2+ over other metal ions in PBS buffered (20 mM, pH = 7.4) solution, the detection limit of QBDA for Hg2+ was estimated to be 2.04 x 10(-8) M and the potential interference from Ag+ can be suppressed in PBS buffered normal saline solution. Living cell imaging investigations show that QBDA possesses good cell permeability, and can act as a light-up imaging probe for Hg2+ ions in MCF-7 cell.

• 出版日期2017-5-1
• 单位北京矿冶研究总院; 渤海大学