Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients - A Pilot Study

作者：Nemeth Balazs^*; Kiss Istvan; Peter Ivan; Ajtay Zeno; Nemeth Adam; Mark Laszlo; Csorba Attila; Koszegi Tamas; Muhl Diana; Kustan Peter

来源：In Vivo, 2016, 30(5): 663-669.

• Sepsis
• L-arginine
• asymmetric dimethylarginine
• nitric oxide
• survival

Background/Aim: Nitric oxide (NO) pathway plays a major role in the development and advancement of inflammation. We aimed to design a study and investigate its feasibility to show the changes of L-arginine, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), which are important regulators of the NO pathway. Patients and Methods: Concentrations of L-arginine, ADMA and SDMA were measured by liquid chromatographytandem mass spectrometry. Seventeen septic survival patients were enrolled and blood samples were obtained on the first, third and fifth day after the diagnosis of sepsis. Sixteen non-septic matched controls were recruited. Results: ADMA levels on admission correlated well with sequential organ failure assessment (SOFA) score. During the follow-up, Larginine/ADMA ratio increased significantly from day 1 to day 3 (p=0.005), then decreased from day 3 to day 5 (p=0.023). Conclusion: This study design seems feasible to investigate changes of L-Arginine, ADMA and SDMA in sepsis survival patients.

• 出版日期2016-10