alpha(v)beta(3)-Integrin-targeting lanthanide complex: Synthesis and evaluation as a tumor-homing luminescent probe

作者：Ito Takeo^*; Inoue Masaki; Akamatsu Kanako; Kusaka Eriko; Tanabe Kazuhito; Nishimoto Sei ichi

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(12): 3515-3518.

DOI：10.1016/j.bmcl.2011.05.001

• Cyclic RGDfK peptides
• Time-resolved fluorescence imaging
• U87-MG
• Macrocyclic compound
• Lanthanide complexes

The application of lanthanide complexes in the time-resolved fluorescence imaging of living cells has emerged in the last few decades, providing high-contrast images of cells through detection of the delayed emission. In the present study, we synthesized novel trivalent lanthanide complexes containing the cyclic peptide c(RGDfK) to visualize the alpha(v)beta(3)-integrin-expressing tumor cells. Conjugation of c(RGDfK) with the macrocyclic bipyridine ligand had little effect on the fluorescence properties of the complex, indicating that the coordinated lanthanide ion was well isolated from the peptide. Bright luminescence images of alpha(v)beta(3)-integrin-expressing U87-MG cells were successfully obtained by employing the probes.

• 出版日期2011-6-15