Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species

作者：Yang, Ye; Zhu, Yaping^*; Xi, Xiaowei^*

来源：Oncology Letters, 2018, 16(3): 2771-2776.

DOI：10.3892/ol.2018.9023

• hydrogen
• reactive oxygen species
• anti-inflammatory
• antitumor

Hydrogen (H-2) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H-2 can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or saline to produce H-2 water or H-2-rich saline. H-2 selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (<bold>OH</bold>) and peroxynitrite (ONOO-), which serve a causative role in the promotion of tumor cell proliferation, invasion and metastasis, but do not disturb metabolic oxidation-reduction reactions in cell signaling. Compared with traditional antioxidants, H-2 is a small molecule that can easily dissipate throughout the body and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H-2 may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti-inflammatory and anti-tumorigenic action of H-2 via ROS.

• 出版日期2018-9
• 单位上海交通大学