Direct synthesis of 5-aryltriazole acyclonucleosides via Suzuki coupling in aqueous solution

作者：Zhu Ruizhi; Qu Fanqi; Quelever Gilles; Peng Ling^*

来源：Tetrahedron Letters, 2007, 48(13): 2389-2393.

DOI：10.1016/j.tetlet.2007.01.154

5-Aryltriazole acyclonucleosides with various aromatic groups on the triazole ring were synthesized via the Suzuki coupling reaction in aqueous solution and promoted by microwave irradiation. Careful optimization of the reaction conditions led in good to excellent yields to the Suzuki products, while the cyclization side-reaction could be completely suppressed.

• 出版日期2007-3-26
• 单位武汉大学