Upregulation of mir-221 and mir-222 in atypical teratoid/rhabdoid tumors: potential therapeutic targets

作者：Sredni Simone Treiger^*; Bonaldo Maria de Fatima; Costa Fabricio Falconi; Huang Chiang Ching; Hamm Christopher Allan; Rajaram Veena; Tomita Tadanori; Goldman Stewart; Bischof Jared Marshall; Soares Marcelo Bento

来源：Child's Nervous System, 2010, 26(3): 279-283.

DOI：10.1007/s00381-009-1028-y

• Atypical teratoid/rhabdoid tumors
• miR221
• miR222
• p27(Kip1)

The aim of this study is to search for new therapeutic targets for atypical teratoid-rhabdoid tumors (ATRT).
To achieve this, we compared the expression of 365 microRNAs among ATRT, medulloblastomas, and normal brain.
MiR-221 and miR-222 were within the top differentially expressed microRNAs. The deregulated expression of miR221/222 was demonstrated to inhibit the expression of the tumor suppressor and inhibitor of cell cycle p27(Kip1). Here, we demonstrated the negative regulation of p27(Kip1) by miR-221/222 in ATRT using microarray, real-time reverse transcriptase polymerase chain reaction, and immunohistochemistry.
As anti-miR therapy was recently proposed as an alternative treatment for cancer, these findings suggest that anti-miR-221/222 therapy might have therapeutic potential in ATRT.

• 出版日期2010-3
• 单位西北大学