A novel method of surface modification by electrochemical deoxidation: Effect on surface characteristics and initial bioactivity of zirconia

作者：Liu, Juan; Hong, Guang^*; Wu, Yu-Han; Endo, Kosei; Han, Jian-Min; Kumamoto, Hiroyuki; Wada, Takeshi; Kato, Hidemi; Gao, Ping^*; Sasaki, Keiichi

来源：Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2017, 105(8): 2641-2652.

DOI：10.1002/jbm.b.33805

• NANOZR
• electrochemical deoxidation
• surface characteristics
• MC3T3-E1
• bioactivity

The aim of this study was to investigate and compare the surface characteristics and initial bioactivity of ceria-stabilized zirconia/alumina nanocomposite (NANOZR) with those of yttria-stabilized zirconia (3Y-TZP) and pure titanium (CpTi) following the use of three surface modification methods; polishing, sandblasting/acid-etching (SB-E) and electrochemical deoxidation (ECD). Physical properties including surface morphology, chemical composition, X-ray diffraction, surface wettability, surface roughness, and hardness were measured. Osteoblast-like MC3T3-E1 cells were used to examine cell morphology and attachment to the surfaces of the materials. ECD treated NANOZR (NANOZR-E) showed a well-arranged, self-organized microporous surface structure with significantly low contact angles when compared with the other specimens (p<0.05). NANOZR-E also demonstrated a slight decrease in monoclinic phase content (-4.4 wt %). The morphology and attachment of MC3T3-E1 cells on NANOZR-E were similar to those on polished and SBE-treated CpTi surfaces. Higher cell affinity was observed on NANOZR-E when compared with ECD treated 3Y-TZP. The findings of this study indicate the effectiveness of the novel technique, ECD, in the formation of a microporous surface on NANOZR when compared with both CpTi and 3Y-TZP. Moreover, this method also appears to improve the biological activity of NANOZR during the initial stage.

• 出版日期2017-11
• 单位天津医科大学; 北京大学