Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice

作者：Beverdam Annemiek; Svingen Terje; Bagheri Fam Stefan; Bernard Pascal; McClive Peter; Robson Mathew; Khojasteh Mahdi Banan; Salehi Mahboubeh; Sinclair Andrew H; Harley Vincent R; Koopman Peter^*

来源：Reproduction, 2009, 137(3): 481-486.

DOI：10.1530/REP-08-0336

Glutathione S-transferases (GSTs) are an important family of multifunctional enzymes that play a role in the protection of tissues by the detoxification of hazardous and carcinogenic compounds. We found previously that Gstm6 is upregulated in the somatic cells of male mouse fetal gonads relative to female gonads. In this study, we describe the spatial and temporal expression pattern of Gstm6 during mouse development. We show that Gstm6 is predominantly expressed in the reproductive system, at significantly higher levels in XY gonads compared with XX gonads from 11.5 dpc onwards, and remains expressed in the testes in adult mice. Its expression is associated with the Sertoli cell lineage, and is dependent on the expression of the male sex-determining gene Sox9. Our data suggest that Gstm6 plays a male-specific role in gonad development or function, possibly by modulating the exposure of somatic tissue and/or germ cells to endogenous or exogenous toxicants.

• 出版日期2009-3
• 单位河北医科大学