Ankle-brachial index and brachial-ankle pulse wave velocity are associated with albuminuria in community-based Han Chinese

作者：Xu, Xiqi; He, Jinggui; Wang, Shuxia; Zhu, Ping; Chen, Qian; Zhang, Xiujin; Tao, Tao; Wang, Hao; Liu, Jianfeng; Wang, Haijun; Li, Xiaoying^*

来源：Clinical and Experimental Hypertension, 2016, 38(7): 618-623.

DOI：10.1080/10641963.2016.1182177

• Albuminuria
• ankle-brachial index
• brachial-ankle pulse wave velocity
• urinary albumin-to-creatinine ratio
• hypertension

Background/objectives: Our study aimed to explore whether the ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) were associated with albuminuria in community-based Han Chinese. Methods: Total 2127 subjects (860 men and 1267 women) aged 60 years and over were recruited in Beijing. Albuminuria was assessed by the urinary albumin-to-creatinine ratio (UACR) of 30 mg/g. BaPWV was divided by quartile. The logistic regression was used to determine the odds ratio (OR) and 95% confidence intervals (CIs) of ABI and baPWV with albuminuria. Results: ABI was associated with albuminuria in the interaction model (OR 0.89, 95% CI 0.81-0.99 by every 0.1 unit increase of ABI), especially in hypertension (OR 0.82, 95% CI 0.73-0.92) and diabetes (OR 0.83, 95% CI 0.68-0.98) groups. BaPWV groups were also significantly associated with albuminuria, ORs of having albuminuria for baPWV quartile II, III, and IV were 1.02(0.65-1.52), 1.05(0.72-1.61), and 1.18(1.04-1.47) in the interaction model. For hypertension and diabetes patients, only the baPWV quartile IV group had higher OR. Conclusions: ABI and baPWV were associated with albuminuria after adjusting for other risk factors in Chinese community-based elderly Han population. The association of ABI with albuminuria was stronger in hypertension and diabetes patients.

• 出版日期2016
• 单位中国人民解放军总医院