Nanotechnologies for biomolecular detection and medical diagnostics

作者:Cheng MMC; Cuda G; Bunimovich YL; Gaspari M; Heath JR; Hill HD; Mirkin CA; Nijdam AJ; Terracciano R; Thundat T; Ferrari M*
来源:Current Opinion in Chemical Biology, 2006, 10(1): 11-19.
DOI:10.1016/j.cbpa.2006.01.006

摘要

Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.