Hemochromatosis Gene (HFE) Polymorphisms and Risk of Type 2 Diabetes Mellitus: A Meta-Analysis

作者：Rong, Ying; Bao, Wei; Rong, Shuang; Fang, Min; Wang, Di; Yao, Ping; Hu, Frank B.; Liu, Liegang^*

来源：American Journal of Epidemiology, 2012, 176(6): 461-472.

DOI：10.1093/aje/kws126

• diabetes mellitus
• type 2
• hemochromatosis
• meta-analysis
• polymorphism
• single nucleotide

The hemochromatosis gene (HFE) has been involved in the etiology of type 2 diabetes mellitus and investigated in numerous epidemiologic studies. The current meta-analysis was conducted to evaluate the gene-disease association in relevant studies. Electronic literature search was performed on June 18, 2011, from databases of PubMed/MEDLINE, EMBASE, and HuGE Navigator. Articles were inspected by 2 authors independently, and data were extracted by identical extraction form. A total of 5,528 type 2 diabetes cases and 6,920 controls in relation to HFE polymorphisms (a cysteine to tyrosine substitution at amino acid position 282 (C282Y) and a histidine to aspartate substitution at amino acid position 63 (H63D)) were included in the meta-analysis (19972011). A fixed- or random-effect model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. An increased odds ratio for type 2 diabetes mellitus was observed in persons carrying a D allele at the H63D polymorphism compared with those with an H allele (odds ratio (OR) 1.21, 95 confidence interval (CI): 1.03, 1.41; P 0.02). Moreover, carriers of a D allele had a modestly increased risk compared with persons with the wild genotype (OR 1.12, 95 CI: 1.00, 1.25; P 0.04). The C282Y variant was not significantly associated with diabetes risk. In summary, persons with a D allele may have a moderately increased risk of type 2 diabetes mellitus.

• 出版日期2012-9-15
• 单位华中科技大学