AEG-1 is associated with tumor progression in nonmuscle-invasive bladder cancer

作者：Yang, Guoliang; Zhang, Lianhua; Lin, Shilong; Li, Linfeng; Liu, Mengyao; Chen, Haige; Cao, Ming; Liu, Dongming; Huang, Yi-ran; Bo, Juanjie^*

来源：Medical Oncology, 2014, 31(6): 986.

DOI：10.1007/s12032-014-0986-4

• AEG-1
• Bladder cancer
• Prognosis
• Progression

Astrocyte elevated gene-1 (AEG-1), a novel oncoprotein, has been implicated in oncogenesis and cancer progression in various types of human cancers. Here, immunohistochemistry was used to detect AEG-1 expression in nonmuscle-invasive bladder cancer (NMIBC), and these data were examined for correlation with clinicopathological parameters, and prognosis. Immunohistochemical analysis revealed that AEG-1 expression was significantly higher in bladder cancer tissues than that in normal tissues. High expression of AEG-1 was found in 45 % of bladder cancers and significantly associated with tumor grade (P = 0.002) and progression (P = 0.028). The Kaplan-Meier survival analysis demonstrated that AEG-1 expression was significantly associated with shorter progression-free survival (P = 0.0011). Multivariate analysis further demonstrated that AEG-1 was an independent prognostic factor for patients with BC. AEG-1 protein may contribute to the malignant progression of bladder cancer, and present as a novel marker to predict the progression of NMIBC.

• 出版日期2014-6
• 单位上海交通大学