The role of in vivo beta-adrenergic stimulation on sweat production during exercise

作者：Buono Michael J^*; Gonzalez Gabriela; Guest Shaun; Hare Arabella; Numan Travis; Tabor Brian; White Ailish

来源：Autonomic Neuroscience-Basic & Clinical, 2010, 155(1-2): 91-93.

DOI：10.1016/j.autneu.2009.12.006

• Sweat
• Exercise
• Atropine
• Adrenergic stimulation
• Iontophoresis

The purpose of the current study was to investigate the role of in vivo beta-adrenergic stimulation on sweat production during exercise. To do this, atropine was used to block the cholinergic component of sweating, thus isolating any potential beta-adrenergic response during exercise. The subjects for this study were 11 healthy volunteers. Atropine (1% solution) and aminophylline (1% solution) were administered to a 5 cm(2) area of the flexor surface of one forearm via iontophoresis. The opposing arm underwent iontophoresis with a saline solution. Each subject then exercised at 75% of their age-predicted maximum heart rate. During exercise, mean +/- SD sweat rate in the control forearm was 0.63 +/- 0.50 mg/cm(2)/min. There was no measurable sweat production in the arm pre-treated with atropine and aminophylline. Following exercise, iontophoresis of pilocarpine verified complete cholinergic blockade in the treated forearm. The results of the current study suggest that in vivo beta-adrenergic stimulation alone is not sufficient to elicit sweating in exercising humans. Such data supports previous studies that have suggested that the role of beta-adrenergic stimulation in vivo is to potentiate cholinergic sweating.

• 出版日期2010-6-24