A Rapid Approach to the Synthesis of Highly Functionalized Tetrahydroisoquinolines

作者:Thansandote Praew; Gouliaras Christina; Turcotte Savard Marc Olivier; Lautens Mark*
来源:Journal of Organic Chemistry, 2009, 74(4): 1791-1793.
DOI:10.1021/jo8025725

摘要

A palladium-catalyzed domino ortho-alkylation/alkenylation forming up to three new C-C bonds furnishes functionalized tetrahydroisoquinolines in up to 87% yield. Extension to the formation of tetrahydrobenzoazepines and tetrahydroisoquinolinones is presented.

  • 出版日期2009-2-20