Neurocognitive impairment and psychiatric comorbidity in well-controlled human immunodeficiency virus-infected Thais from the 2NN Cohort Study

作者：Pumpradit Wadchara^*; Ananworanich Jintanat; Lolak Sermsak; Shikuma Cecilia; Paul Robert; Siangphoe Uma****; Chaoniti Nithima; Kaew On Peera****; Paris Robert; Ruxrungtham Kiat; Valcour Victor

来源：Journal of NeuroVirology, 2010, 16(1): 76-82.

DOI：10.3109/13550280903493914

• cognition
• dementia
• HIV
• HAART

This research is a cross-sectional study to determine the frequency of neurocognitive impairment and psychiatric comorbidity among Thais maintained on highly active antiretroviral therapy (HAART) with undetectable plasma human immunodeficiency virus (HIV) RNA in the 2NN Cohort. Sixty-four subjects were evaluated with neurological examinations, neuropsychological testing, and psychiatric questionnaires. Twenty-four subjects (37.5%) were found to have neurocognitive impairment, with 13 (20.3%), 10 (15.6%), and 1 (1.6%) classified as asymptomatic neurocognitive disorder (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD), respectively. Three subjects (4.7%) had depression and no cases had significant symptoms of anxiety. A notable proportion of well-controlled individuals exhibited neurocognitive impairment. Anxiety and depression were uncommon.</.

• 出版日期2010-2
• 单位河北医科大学