Application of the diffusion kurtosis model for the study of breast lesions

作者：Nogueira Luisa^*; Brandao Sofia; Matos Eduarda; Nunes Rita Gouveia; Loureiro Joana; Ramos Isabel; Ferreira Hugo Alexandre

来源：European Radiology, 2014, 24(6): 1197-1203.

DOI：10.1007/s00330-014-3146-5

• Diffusion weighted imaging
• Diffusion kurtosis imaging
• Magnetic resonance imaging
• Breast lesions
• Mean kurtosis

To evaluate diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) in the differentiation and characterisation of breast lesions. %26lt;br%26gt;Thirty-six women underwent breast magnetic resonance imaging (MRI) including a DWI sequence with multiple b-values (50-3,000 s/mm(2)). Mean values for apparent diffusion coefficient (ADC), mean diffusivity (MD) and mean kurtosis (MK) were calculated by lesion type and histological subtype. Differences and correlation between parameters were determined. %26lt;br%26gt;Forty-four lesions were found. There were significant differences between benign and malignant lesions for all parameters (ADC, p = 0.017; MD, p = 0.028; MK, p = 0.017). ADC and MD were higher for benign (1.96 +/- 0.41 x 10(-3) and 2.17 +/- 0.42 x 10(-3) mm(2)/s, respectively) than for malignant lesions (1.33 +/- 0.18 x 10(-3) and 1.52 +/- 0.50 x 10(-3) mm(2)/s). MK was higher for malignant (0.61 +/- 0.27) than benign lesions (0.37 +/- 0.18). We found differences between invasive ductal carcinoma (IDC) and fibroadenoma (FA) for all parameters (ADC, MD and MK): p = 0.016, 0.022 and 0.016, respectively. FA and fibrocystic change (FC) showed differences only in MK (p = 0.016). %26lt;br%26gt;Diffusion in breast lesions follows a non-Gaussian distribution. MK enables differentiation and characterisation of breast lesions, providing new insights into microstructural complexity. To confirm these results, further investigation in a broader sample should be performed. %26lt;br%26gt;aEuro cent The diffusion kurtosis model provides new information regarding breast lesions %26lt;br%26gt;aEuro cent MD and MK are valid parameters to characterise tissue microstructure %26lt;br%26gt;aEuro cent MK enables improved lesion differentiation %26lt;br%26gt;aEuro cent MK is able to differentiate lesions that display similar ADC values.

• 出版日期2014-6