Genetic characterization of resistance to extended-spectrum beta-lactams in Klebsiella oxytoca isolates recovered from patients with septicemia at hospitals in the Stockholm area

作者：Wu SW^*; Dornbusch K; Kronvall G

来源：Antimicrobial Agents and Chemotherapy, 1999, 43(5): 1294-1297.

Two beta-lactamase gene regions were characterized by DNA sequencing in eight clinical isolates of Klebsiella oxytoca. The bla(OXY-2a) region encoded a beta-lactamase nearly identical to OXY-2 (one amino acid residue substituted) and conferred aztreonam and cefuroxime resistance on the K. oxytoca isolates. Overproduction of OXY-2a was caused by a G-to-A substitution of the fifth nucleotide in the -10 consensus sequence of bla(OXY-2a). The bla(OXY-1a) was identified in a susceptible strain, and the OXY-la enzyme differed from OXY-1 by two amino acid residues.

• 出版日期1999-5